Bronchoscopic Techniques May Be the Future of Lung Cancer Diagnosis, Treatment

Lung cancer is the leading cause of cancer death worldwide. Stage 1 non-small-cell lung cancer can be effectively cured by surgery or radiotherapy, but Stage 4 lung cancer carries a very poor prognosis. Improved survival depends on diagnosing lung cancer in the early asymptomatic stages; the only effective way of doing this currently is CT-based lung cancer screening to identify nodules for evaluation and risk-stratification (usually those 8 mm or larger). The ability to efficiently biopsy and accurately diagnose CT-identified high-risk lung nodules will be key to improving overall survival of this devastating disease, and bronchoscopic techniques stand to play an increasingly important role. Continue Reading >

First U.S. Patients Receive Targeted Lung Denervation Therapy at Temple

Temple introduced a new experimental COPD treatment to the United States in June, completing targeted lung denervation (TLD) procedures on three patients. Gerard J. Criner, MD, FACP, FACCP, Lung Center Director, Chair and Professor of Thoracic Medicine and Surgery at the Lewis Katz School of Medicine, headed the team that treated the first three U.S. patients as part of the AIRFLOW-3 international clinical trial. Continue Reading >

Case Study: Rapidly Progressive ILD with Right Ventricular Failure

A 40-year-old male never-smoker with a past medical history of non-ischemic heart failure, beta thalassemia, sickle-cell trait, and interstitial lung disease presented to the TUH emergency room with chest pain. He was found to have a large left pneumothorax that was treated with tube (8Fr) thoracostomy. A right pneumothorax, a week prior to this presentation, was treated at another hospital. His first abnormal chest X-ray result was found about two years ago at a different emergency room. Since that time, his shortness of breath progressed rapidly. Continue Reading >

New Online Tool to Improve AATD Diagnosis

Alpha-1 antitrypsin deficiency (AATD) is associated with lung and liver disease, and less commonly with necrotizing panniculitis (a skin disorder) and a type of vasculitis. Early diagnosis of AATD is crucial to help slow disease progression—yet, because alpha-1 antitrypsin (AAT) levels fluctuate, accurate diagnosis by conventional quantitative blood tests can be challenging. A new algorithm developed at Temple is now available online to help physicians make a more definitive determination of baseline AAT levels and improve diagnostic speed and accuracy. Continue Reading >

CT and the Fight Against Lung Cancer

Computed tomography (CT) lung-imaging technology has evolved tremendously over the decades since its advent in 1967. Development of faster helical scanners with high resolution has made sub-second scanning possible. This enables us to obtain high-quality images and re-create movement throughout the lungs in dynamic imaging, while sometimes reducing the radiation dose received by the patient. Fast scanning also allows us to obtain imaging scans without patients having to hold their breath for long durations. Modern scanners allow us to view thin slices across lung tissue to pinpoint and examine any issues with greater accuracy. Continue Reading >

Collaborative Treatment for ILD Patients with Connective Tissue Disease

Connective tissue diseases in about 11% of patients can be associated with interstitial lung disease (i.e., CT-ILD). The CT-ILD may cause inflammation of the lungs or fibrosis, or in some cases, both. Additionally, patients require assessment and treatment of their underlying rheumatologic disorder. The Temple Lung Center, in collaboration with the Temple Department of Rheumatology, has formed a joint clinic specifically for the care of ILD patients with possible connective tissue disease. Continue Reading >